Anticomplementary activity of triterpenoides from fruits of. Cyclopeptide alkaloids from zizyphus jujuba request pdf. For the first time 12 reported six cyclopeptide alkaloids isolated from. Department of biology, payame noor university, po box 193953697, tehran, i. Compound 2, 3 showed potent inhibitory effects on porcine epidemic diarrhea virus replication. Six novel ia3type cyclopeptide alkaloids 16 were isolated from stems of ziziphus apetala. Phenolic compounds from seeds of zizyphus spinachristi ataa said1, antje huefner 2, elsayed a. The genus zizyphus belongs to family rhamnaceae which comprises of 58. The structures were elucidated by 1 and 2dnmr techniques. Zizyphus jujuba and its active component jujuboside b inhibit. Five cyclopeptide alkaloids, sativaninec, mauritinea, mauritined, amphibineb and nummularinek has been isolated from the bark of zizyphus rugosa and their structures were established by spectral evidences. Pseudoalkaloids alkaloidlike compounds that do not originate from amino acids. Till now eighty one cyclopeptide alkaloids are reported from various zizyphus species.
The seeds are used in chinese medicine as a sedative. Review article potential benefits of jujube zizyphus lotus. To the best of our knowledge, only one publication has reported cyclopeptide alkaloids from the z. The cyclopeptide alkaloid fraction from ziziphi spinosi semen, defined as the dried seed of ziziphus jujuba mill. In this study we isolate two new cyclic amino acids from the seeds of zizyphus spinachristi l. Phytochemical screening of different organic crude extracts. The isolation of cyclopeptide alkaloids, frangufoline from zizyphus jujuba and z.
A new cyclopeptide alkaloid, jubaninec 1, together with known alkaloids scutianinec 4 and zizyphinea 5, have been isolated from the stem bark of zizyphus jujuba and identified by spectral. In the last few decades there has been an exponential growth in the field of herbal medicine. The seed, which known as suan tsao zen in china, is a famous chinese medicine that is used for the treating insomnia. The study showed that zizipus jujuba plant can be used to obtained antibiotics having less or no side effect, especially against salmonella and staphylococcus aureus infections. Phytochemical, antimicrobial and cytotoxic evaluation of ziziphus spinachristi l. Terpenoids, flavonoids, alkaloids, phenolics, and fatty acids were reported as chemical compounds from the seed of z.
In addition to the known alkaloid mucronined, two new cyclopeptide alkaloids were isolated from the roots of ziziphus mucronata. Jubanines fj, cyclopeptide alkaloids from the roots of. Cyclopeptide alkaloids are macrocyclic compounds, the ring system of which consists of a hydroxystyrylamine moiety, an amino acid and a. In this work we hypothesized that this natural product rich in polyphenols might protect humans against dna damage and its consequences. This enables the jujube to grow in mountain or desert habitats, provided there is access to underground water throughout the summer. These small acid fruits are liked by children as well as by adults. Recently, several scientific reports for health benefit and nutritional potential of bioactive compounds from this. Cheval besides the already described amphibinea, from the bark of ziziphus amphibia a. Abu tabl 3, gehan fawzy1 1national research centre, pharmacognosy department, dokki, cairo, egypt. Rjpp phytochemistry and pharmacology of indian medicinal. This plant is a thorny rhamnaceous plant that is widely distributed in europe and southeastern asia. Zizyphus lotus, belonging to the rhamnaceae family, is a deciduous shrub which generally grows in arid and semiarid regions of the globe. Chemical compounds in the seeds of ziziphus jujuba var.
Inhibition of calmodulindependent calciumatpase and phosphodiesterase by various cyclopeptides and peptide alkaloids from the zizyphus species. A new 14membered cyclopeptide alkaloid from zizyphus. Sep 18, 2019 ziziphus jujuba chinesekorean date, jujube is a plant which bears fruits and seeds that are used for medicinal purposes in traditional chinese medicine. They are widely distributed among plants of the rhamnaceae family, but their occurrence has also been confirmed in representatives of asteraceae, celastraceae. This includes thirty five membered, thirty nine 14membered and seven 15membered ring cyclopeptides in. Functional benefits of ziziphus jujuba fruits ecronicon. Three new cyclopeptide alkaloids from zizyphus species. In one clinical trial in china 12 patients with liver complaints were given jujube, peanuts and brown sugar nightly. A new cyclopeptide alkaloid, jubaninec 1, together with known alkaloids scutianinec 4 and zizyphinea 5, have been isolated from the stem bark of zizyphus jujuba and identified by. The cyclopeptide alkaloid, mauritine j, was isolated from the root bark of z. These alkaloids are mauritine a and seven ibtype cyclopeptide alkaloids. The seeds of zizyphus jujuba szj, a famous oriental traditional medicine, have been reported to exhibit diverse activities in biological systems including the cardiovascular system.
Compound 5 and the known compounds mauritine a 7 and mauritine f 8 were isolated from the roots. T he chem ical com pounds in the seeds of ziziphus jujuba var. Cyclopeptide alkaloids reported from zizyphus species. Ziziphus jujuba supplement health benefits, dosage, side. Crude extract from ziziphus jujuba fruits, a weapon against pediatric infectious disease daneshmand f phd1, zarezardini h msc2, 3, tolueinia b msc4, hasani z msc5, ghanbari t msc6 1. Their structures were determined by spectroscopic analyses and chemical methods. This has led to our investigation to find out if the fruit extract showed an ability to decrease the frequency of dna damage antigenotoxicity induced by two. The dried fruits contain saponins, triterpenoids and alkaloids. Mechanism of the growth inhibitory effects of zizyphus jujuba and green tea extracts in human hepatoma cells. However, little information is available on its antiplatelet activity. Cyclopeptide alkaloids from ziziphus apetala journal of. This group includes terpenelike and steroidlike alkaloids, as well as purinelike alkaloids such as caffeine, theobromine, theacrine and theophylline. T erpenoids, flavonoids, alkaloids, phenolics, and fatty acids w ere reported as chem ical com pounds from the seed of z.
Ziziphus zizyphus jujubaber, chinese dateselantha medicinal usesplant descriptionchemical constituents. Pdf cyclopeptide alkaloids of zizyphus species researchgate. A small spreading tree, with drooping branches grows readily and quickly on poor ground. Pdf a cyclopeptide alkaloid from the bark of zizyphus rugosa. Cyclopeptide alkaloids are defined as basic compounds embodying an ansa structure, in which a 10 or 12membered peptide type bridge spans the 1,3 or 1,4 positions of a benzene ring 1.
The chemical compounds in the seeds of ziziphus jujuba var. A new 14membered cyclopeptide alkaloid from zizyphus oxyphylla article pdf available in natural product research 2. The two compounds were identified by means of 1 hnmr cnmrhsqchmbc and gcms as 4hydroxymethyl1methyl pyrrolidine2carboxylic acid less polar and major compound and 4hydroxy4hydroxymethyl1methyl pyrrolidine2carboxylic acid more polar and minor. Cyclopeptide alkaloids from some ziziphus plants swu institutional. Review article potential benefits of jujube zizyphus lotus l. Seoul 110460, republic of korea abstract u with reference to the clinical importance of sanjoin, the. It is getting popularized in developing and developed countries owing to its natural origin and lesser side effects. Ziziphus jujuba, ziziphus sativa, ziziphus vulgaris, zizyphus mauritiana family. Two new cyclopeptide alkaloids, xylopyrined and xylopyrinee, from zizyphus xylopyra and a new alkaloid, jubaninee, from zizyphus jujuba have been. Phytochemical, antimicrobial and cytotoxic evaluation of. Pdf cyclopeptide alkaloids from zizyphus rugosa bark.
Five ibtype cyclopeptide alkaloids, jubanines f j 15 were isolated from the roots of ziziphus jujuba. It may possess anxietyreducing and sedative properties. Studies on the chemical cons tituents from the seeds of. Japanese research has shown that jujube increases immunesystem resistance. Zizyphus is used for improving muscular strength and weight, for preventing liver and.
Dec 07, 2016 recently, several scientific reports for health benefit and nutritional potential of bioactive compounds from this jujube have been reported. Cyclopeptide alkaloids from zizyphus jujuba sciencedirect. A new cyclopeptide alkaloid, jubaninec 1, together with known alkaloids scutianinec 4 and zizyphinea 5, have been isolated from the stem bark of zizyphus jujuba and identified by spectral analysis. Inhibitory effect of heracleum persicum and ziziphus jujuba. Chemical and pharmacological studies on sedative cyclopeptide alkaloids in some rhamnaceae plants byung hoon han, myung hwan park and jeong hill park natural products research institute, seoul national university, 28, yunkeunudong, chongnoku. Chemical and pharmacological studies on sedative cyclopeptide. Antiplasmodial and antimycobacterial cyclopeptide alkaloids from the root of ziziphus mauritiana panomwan panseetaa, kanlaya lomchoeya, samran prabpaib, palangpon kongsaereeb,c, apichart suksamrarnd, somsak ruchirawate, sunit suksamrarna.
Phenolic compounds from seeds of zizyphus spinachristi. Five or more other species of ziziphus are widely distributed in milder climates to hot deserts of asia and africa. The results of this study showed that methanolic extracts of h. Invitro efficacy of crude extract of zizipus jujuba against. Pharmacological and phytochemical studies of genus zizyphus. The generic name zizyphus has been resulting as of zizouf, the arabic name of zizyphus lotus bailey, 1947. Phytopharmacology of ziziphus jujuba mill pharmacognosy. Uses, side effects, interactions, dosage, and warning. Cyclopeptide alkaloids from ziziphus mucronata sciencedirect. Amphibineb, c, d, and e, four peptide alkaloids from ziziphus amphibia a. C hem ical com pounds in the seeds of z iziphus jujuba var.
One such medicinal plant is ziziphus jujuba mill, a member of the family rhamnaceae, commonly known as bor, grows mostly in europe, southern and eastern asia, and australia, especially. Antiplasmodial and antimycobacterial cyclopeptide alkaloids. Inhibition of calmodulindependent calciumatpase and. Potential antigenotoxicity assessment of ziziphus jujuba.
Ziziphus jujuba, ziziphus sativa, ziziphus vulgaris, zizyphus. Various phytochemicals are present in the zizyphus jujuba var. The isolation of cyclopeptide alkaloids, frangufoline from zizyphus jujuba. Pdf cyclopeptide alkaloids isolated from the genus zizyphus until. Original article crude extract from ziziphus jujuba fruits, a. The purpose of this study was to investigate the inhibitory effect of heracleum persicum and ziziphus jujuba on the activity of alphaamylase. Essam nabih ads 1, saravanan rajendrasozhan 1, syed imran hassan 1,3, sherif mohamed sayed sharawy 1,4 and jamal ragheb humaidi 1. Index terms efficacy, zizipus jujuba, antibacterial activity, cold water extract, zone of inhibition. A new cyclopeptide alkaloid, jubaninec 1, together with known alkaloids scutianinec 4 and zizyphinea 5, have been isolated from the stem bark of. This plant is rich in polyphenols, cyclopeptide alkaloids, dammarane saponins, vitamins, minerals, amino acids, and polyunsaturated fatty acids. Phytochemical screening of different organic crude extracts from the stem bark of ziziphus spinachristi l.
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